UCLA Physical Sciences Patents

Physical Sciences faculty and researchers have used their curiosity to create important innovations for everyday life. Many of the patents listed below have helped people discover unknowns, cure diseases, and understand society’s greatest issues.


Math Patents

Andrea Bertozzi

Automated Activity Classification of Video from Body Worn Cameras

Data Fusion Mapping Estimation

Rapid Computational Technique for Inpainting of High Contrast Images

Determining oil well connectivity using nanoparticles

Tom Chou

A Novel rapid and Highly Sensitive Cell Based System for the Detection and Characterization of HIV

Robert Edwards

Method for Screening Data Opioid Receptor Modulators

Ker Chau Li

Liquid Association with Application in Gene Expression

Very-Small-Nuclear Circulating Tumor Cell (vsnCTC) as a Diagnostic Biomarker of Visceral Metastasis in Advanced Prostate Cancer

Stanley Osher

Volumetric Analysis of Multi-dimensional images

Determining Oil Well Connectivity Using Nanoparticles

Rafail Ostrovsky

Method and System for Pick and Drop Sampling from Large Dataset

Private Keyword Search on Streaming Data

Provably Secure Virus Detection

Optimal Routing Protocol Secure against Malicious Adversary

Efficient Translation from Edit Distance to Hamming Distance

Joseph Teran

A polynomial Particle-In-Cell Method

Anisotropic Elastoplasticity for Codimensional Frictional Contact

Statistics Patents

Song-Chun Zhu

A new Format for Representing and Encoding Images

Yi Xing

Methods for Modulating and Assaying M6a in Stem Cell Populations

DARTS: Deep Learning Augmented RNA-seq Analysis of Transcript Splicing

Ying Nian Wu

A New Format for Representing Encoding Images

Ker Chau Li

Liquid Association with Application in Gene Expression

Very-Small-Nuclear Circulating Tumor Cell (vsnCTC) as a Diagnostic Biomarker of Visceral Metastasis in Advanced Prostate Cancer

Ariana Anderson

Predicting the Placebo Response and Placebo Responders in Medicated and Unmedicated Patients Using Baseline Psychometric and Clinical Assessment Score

Physics and Astronomy Patents

Katsushi Arisaka

Radiation Free Photon Detection Device

George Gruner

Charge Storage Device Containing Carbon Nanotube Films

Flexible Nanotube Transistors

Thomas Mason

Tracking Anisotropic Shapes In Digital Image Sequences At High Resolution

Novel Multi-Scale Pre-Assembled Phases of Matter

Fabrication Of Custom Particles Using Relief Radiation Templating

Measuring Size Distributions of Small-Scale Objects

Litho-particle Dispersions: Designer Particles with Customizable Shapes

Massively Parallel Assembly of Composite Structures using Depletion Attractions

Process for Directing Assemblies of Particulate Dispersions Using Surface Roughness

Method of Making Multicomponent Nanoemulsions

Improved Treatment of Acute Metabolic Acidosis

Process For Creating Stable Double Emulsions

Process For Sorting Dispersed Colloidal Structures

Process For Recycling Surfactant In Nanoemulsion Production

Mechanical Process For Creating Particles Using Two Plates

Jianwei Miao

Fast Implementation of Equally Sloped Tomography

Seth Putterman

A Compact, Portable, Low-Voltage Linear Photoelectron Accelerator

Observation of Nuclear Fusion Driven by a Pyroelectric Crystal

Ferroelectric Electron and Ion Generator for Small Applications

James Rosenzweig

Mesoscale Photonic Structure Fabrication

Plasma Opening Switch

Method of Localizing Breakdown in higher Power Rf Network

Kang Wang

Fast And Low-Power Sense Amplifier And Writing Circuit For High-Speed MRAM

High Frequency Mixer Based on Non-linear Phenomena in Ferromagnetic Films

Voltage-Controlled Magnetic Tunnel Junction Switch And Magnetic Memory Bit

Epitaxial Growth of Single Crystalline MgO on Germanium

Electric Field Induced Tunable and Metastable Remanent Strain and Remanent Permittivity in Ferroelectrics

Relaxed SiGe Films by Surfactant Mediation

Novel Nanomaterial-based Thermo-Photovoltaic Cells

Graphene Flash Memory Device

Novel Telegraph Signal Microscope For Visualizing Single Atoms And Detecting Defects In Nanotechnology Devices

Vsat Structure for Nonvolatile Memory Device

Vertical-Stacked-Array-Transistor (VSAT) for Nonvolatile Memory Devices

Methods to Efficiently Interconnect Nanoscale Computational Components with Spin-waves

Vertical Gate-Depleted Single Electron Transistors

A Self-Organized Critical CMOS Circuit for Computation and Information Processing

Fabrication Of 1D Sinusoidal Silicon Dioxide Substrate

Anti-Ferromagnetic Magneto-Electric Spin-Orbit Read Logic

Quasi Van Der Walls Epitaxy Of GaAs on Graphene

Periodically Rippled Antenna

Graphene-Polymer Nanocomposite Incorporating Chemically Doped Graphene-Polymer Heterostructure for Flexible and Transparent Conductive Films

Strained Voltage-Controlled Magnetic Memory Elements and Devices

Hanguo Wang

Radiation Free Photon Detection Device

Giovanni Zocchi

Introduction of Artificial Allosteric Sites on Functional Proteins to Externally Control Function and Binding

Radiation Free Photon Detection Device

Chemistry and Biochemistry Patents

Anne Andrews

Determining Oil Well Connectivity Using Nanoparticles

Louis Bouchard

NMR Probe for the Detection of Microstructures

Image Filtering Algorithm for Enhanced Noise Removal and Feature Preservation

Method to Probe Bulk and Surface States in Thermoelectrics and Topological Materials

Reducing Computational Complexity of Training Algorithms for Artificial Neural Networks

Biologically applicable water soluble Heterogeneous Catalysts for Parahydrogen Induced Polarization

Robert Clubb

Reagent to Label Proteins via Lysine Isopeptide Bonds

New Method to Increase the Rate of Protein Ligation Catalyzed by the S. Aureus Sortase A Enzyme

Timothy Deming

Preparation of Functionalized Polypeptides, Peptides, and Proteins by Alkylation of Thioether Groups

Amphiphilic Derivatives of Thioether Containing Block Copolypeptides

Chemoselective Side-Chain Modifications of Methionine-Containing Elastin-Like Polypeptides

Process for Creating Stable Double Emulsions

Preparation of Functional Homocysterine Residues in Polypeptides and Peptides

Compositions of Polyion Complex Polypeptide Hydrogels

Xianfeng Daun

Approaching Schottky-Mott Limit in Van Der Waals Metal Semiconductor Contacts

A General Solution-Processable Approach To High-Quality Two-Dimensional Ink Materials For Printable High-Performance Large-Area And Low-Cost Electronics/Optoelectronics/Thermoelectrics

Electrochemical Molecular Intercalation for Synthesis of Monolayer Atomic Crystal Molecular Superlattices

Upconversion Plasmonic Mapping: A Direct Plasmonic Visualization And Spectrometer-Free Sensing Method

Graphene Nanomesh As A Glucose Sensor

High Stability PtNiX-M Electrochemical Catalyst

Stable Alloy Of Palladium Hydride With High Hydrogen Content

High Performance PtNiCuMo Electrochemical Catalyst

Three-Dimensional Holey Graphene Frameworks Based High-Performance Supercapacitors

Wafer Scale Growth Of Large Arrays Of Perovskite Micro-Plate Crystals For Functional Electronics And Optoelectronics

Vertical Heterostructures for Transistors, Photodetectors, and Photovoltaic Devices

Conductor-Semiconductor Composite Films and Their Applications for High Performance Transistors

A Composite of Two Dimensional Material and One Dimensional Material as Transparent Conductor

Palladium Alloy Hydride Nano Materials

Graphene Based Catalysts for Biomimetric Generation of Antithrombotic Species

Chemical Vapor Deposition Growth of the Large Single Crystalline Domains of Monolayer and Bilayer

Graphene Moisture-Resistive Membrane Cathode for Li-Air Battery in Ambient Conditions

High Performance Thin Films from Solution Processible Two-Dimensional Nanoplates

Graphene Nanomesh As A Continuous Semiconducting Thin Film For Large Scale Field Effect Transistors

Nanoscale Optical Voltage Sensors

Tunable Thz Generation In Chip-Scale Graphene

Ultrafine Nanowires As Highly Efficient Electrocatalysts

Pore Size Engineering Of Porous Carbons Using Covalent Triazine Frameworks As Precursors

High Performance Transition-Metal Doped PtNi Catalysts

The Method of Enhanced Pressure Sensing Performance for Pressure Sensors

Very High Energy Density Silicide-Air Primary Batteries

David Eisenberg

Novel Tau Aggregation Inhibitor Peptide

Inhibition of the Aggregation of Transthyretin by Specific Binding of Peptides to Aggregation-Driving Segments

Drug for Dialysis-related Amyloiodsis

Methods and Materials for Characterizing and Modulating Interaction between Heregulin and HER3

Antimicrobial Peptide for the Treatment of Skin Diseases

Structure-Based Peptide Inhibitors of Alpha-Synuclein Aggregation, A Potential Therapeutic for Parkinson’s Disease

Neil Garg

Cross Coupling of Phenolic Derivatives

Animation of Aryl Alcohol Derivatives

Pathway-Dependent Inhibition of Proteopathic Seed Transmission

Identification And Development Of Dual nSMase2-AChE Inhibitors For Neurodegenerative Disorders

Synthesis Of Heteroatom Containing Polycyclic Aromatic Hydrocarbons

Robin Garrell

Synthesis of Thioether Containing Trialkoxysilanes

Spontaneous Droplet-into-Droplet Insertion for Formation of Polymer Particles

James Gimzewski

Single Molecule DNA Profiling

Observation of Nuclear Fusion Driven by a Pyroelectric Crystal

Ferroelectric elctron and ion Generator for Small Applications

Novel Micro-Calorimeter Device for Drug Discovery and Biochemical Analysis

Single Cell Nanomechanical Stethoscope

Fine Needle Device for the Measurement of Material Properties

Patrick Harran

Small Molecule Antagonists of The Pro-Survival Protein Mcl-1

Kendall Houk

Cyclopentadiene Compounds for use in Bioorthogonal Coupling Reactions

Michael Jung

Combination Therapy Approach Using Novel Biguanides For Cancer Treatment

Allosteric BACE Inhibitors For Treatment Of Alzheimer’s Disease

A Novel Positron Emission Tomography Probe for Imaging Liver Disease and Metabolic Imbalance

Novel Small Molecules that Target Cancer Stem Cells for the Treatment of Cancer

Novel Therapeutic Analogues of Metformin for the Treatment of Cancers

Novel Small Molecule Inhibitors of Endosomal Trafficking for the Treatment of Viral and Bacterial Infection

Second-Generation Estrogen Receptor Down-Regulators for Medical Therapy

Brain Penetrant EGFR Tyrosine Kinase Inhibitors

Preparation and Activity of Novel Photosensitizer Acting as a Broad Spectrum Antiviral Agent Against Enveloped Viruses

Inhibitors Of Ires-Mediated Protein Synthesis

Inhibitors Of The N-Terminal Domain Of The Androgen Receptor

A Novel ER Beta Ligand Prodrug to Treat MS and Other Neurodegenerative Diseases

Inhibition Of Protein Tyrosine Phosphatase – Sigma For Hematopoietic Regeneration

Novel Antiviral Compounds to Treat Enterovirus Infections

Apoe4-Targeted Theraputics That Increase Sirt1

Richard Kaner

Top-Down Fabrication Of Asymmetric, Thin-Film Composite Membranes

High-throughput Solution Processing of Large Scale Graphene for Device Applications

Polyanaline Nanofibers

Rapid Solid-State Metathesis Routes to Nanostructured Silicon-Germanium

Mechanochemical Synthesis of Mg2Si and Related Compounds and Alloys

Nanostructured Polymer Electrodes

Rapid Bulk Synthesis of Carbon Nanotubes and Graphite Encapsulated Metal Nanoparticles

Au Nanoparticles Doped Polyaniline Nanofiber Non-Volatile Memory Device

Enantioseparation of Amino Acids Using a Chiral Recognition Polymer

Polyaniline Nanofiber Composite Materials: New Chemical Sensors for Phosgene

Polyanaline Nanofibers as Hydrogen Sensors

Charles Knobler

Sustained Intracellular RNA Delivery and Expression

In Vitro Reconstituted Plant Virus Capsids For Delivering Rna Genes To Mammalian Cells

Carla Koehler

Small Molecule Modulators of Mitochondrial Protein Import

Methods to Transport RNA into Mitochondria

Ohyun Kwon

Novel Non-Peptidomimetic Prenyltransferase Inhibitors

Small Molecule Inhibitor of Cholesterol Biosynthesis and Venous Angiogenesis

Novel Non-Peptidomimetic Prenyl Transferase Inhibitors

Small Molecule Agonists of VDAC2 to Treat Cardiac Arrhythmias and Heart Failure

Small Molecules that Mimic IFN-Gamma-Mediated Endothelial Cell Activation

Compound Library Made Through Phosphine-Catalyzed Annulation/Tebbe/Diels-Alder Reaction

Thomas Mason

Tracking Anisotropic Shapes In Digital Image Sequences At High Resolution

Novel Multi-Scale Pre-Assembled Phases of Matter

Fabrication Of Custom Particles Using Relief Radiation Templating

Measuring Size Distributions of Small-Scale Objects

Litho-particle Dispersions: Designer Particles with Customizable Shapes

Massively Parallel Assembly of Composite Structures using Depletion Attractions

Process for Directing Assemblies of Particulate Dispersions Using Surface Roughness

Method of Making Multicomponent Nanoemulsions

Improved Treatment of Acute Metabolic Acidosis

Process For Creating Stable Double Emulsions

Process For Sorting Dispersed Colloidal Structures

Process For Recycling Surfactant In Nanoemulsion Production

Mechanical Process For Creating Particles Using Two Plates

Heather Maynard

Dual-Enzyme Responsive Peptides

Trehalose Hydrogels For Stabilization And Delivery Of Proteins

Noncrushable/Nonabusable Pill Formulations

A Novel Glycopolymer to Enhance Protein Stability

A Novel Method for Synthesizing Hydrogels

A Novel Basic Fibroblast Growth Factor Conjugate for Broad Therapeutic Application

Update To Degradable Trehalose Glycopolymers

PolyProtek: Platform for Delivering and Stabilizing Therapeutic Biologics, Vaccines, and Industrial Enzymes

Daniel Neuhauser

Improved Methodology for Detecting and Identifying Position for Microscopy Applications

Jose Rodriguez

Structure-Based Peptide Inhibitors of Alpha-Synuclein Aggregation, A Potential Therapeutic for Parkinson’s Disease

Yves Rubin

Improved Photovoltaic Efficiency in Semiconducting Polymer/fullerene Solar Cells through Control of Fullerene Self-assembly and Stacking

Synthesis of Graphene Nanoribbons From Monomeric Molecular Precursors Bearing Reactive Alkyne Units

Benjamin Schwartz

Improved photovoltaic Efficiency in Semiconducting Polymer/fullerene Solar Cells through Control of Fullerene Self Assembly and Stackin

Ellen Sletten

Improved Shortwave Infrared Polymethine Dyes

Disulfide Bioconjugation

Tunable Linear Fluoropolymers

Alexander Spokoyny

Photophysically Innocent Boron Cluster Ligand Scaffolds for Organic Light Emitting Diode Materials

Carborane-Based Histone Deacetylase (HDAC) Inhibitors

Yi Tang

Methods for Weed Control and Hybrid Seed Production

Redox Responsive Polymeric nanocapsules for Protein Delivery

Sarah Tolbert

Magnetoelectric Control of Superparamagnetism

Improved Photovoltaic Efficiency in Semiconducting Polymer/fullerene Solar Cells through Control of Fullerene Self-assembly and Stacking

Atomic Layer Deposition of Alkali Metal Containing Solid State Electrolyte for 3-D Micro-Batteries

Ordered Vertically Oriented Porous Inorganic Films Produced through Solution Processing

Space Confined Polymer-Based Field Effect Transistors

Chemical Energy Storage Based on Nanoporous Aluminum

Nanoporous Tin Powder For Energy Applications

Robust Mesoporous Nife-Based Catalysts For Energy Applications

Lithium Ion Batteries Based On Nanoporous Silicon

Jorge Torres

Mi-181: A Potent Small Synthetic Microtubule-targeting Anticancer agent

Paul Weiss

Biomimetic Artificial Periodontal Membranes And Method Of Fabricating The Same

Dental Adhesive Hydrogels And Uses Thereof

Multiple-Patterning Nanosphere Lithography

Scalable Lipid Bilayer Microfluidics for High-Throughput Gene Editing

Guided Magnetic Nanospears For Targeted And High-Throughput Intracellular Delivery

Gallium Alloy Nanoparticle Synthesis via Self-Assembled Monolayer Formation and Ultrasound

Determining Oil Well Connectivity Using Nanoparticles

Full Color Quantum Dot Patterning Via Soft Lithography

High-Throughput Microfluidic Gene-Editing via Cell Deformability within Microchannels

High-Throughput Intracellular Delivery of Biomolecular Cargos via Vibrational Cell Deformability within Microchannels

Shimon Weiss

Membrane Insertion of Potential Sensing Nanorods

Ultrahigh Resolution Multicolor Colocalization of Single Fluoresecent Probes

Protein-Protein Interactions as a Tool for Site-Specific Labeling of Proteins

Bioactivation and Surface Properties Modulation of Inorganic Nanoparticles

Method and Apparatus for Photon Arrival Time Interval Distribution (Paid) Analysis in Fluorescence Correlation Spectroscopy

Gerard Wong

Antibiotic-Peptide Conjugates With Anti-Microbial Efficiency Against Chronic Infections

Todd Yeates

Mi-181: A Potent Small Synthetic Microtubule-Targeting Anticancer Agent

A Method to Design Self-Assembling Proteins

A General Method For Designing Self-Assembling Protein Nanomaterials

Jeffrey Zink

A General Method For Designing Self-Assembling Protein Nanomaterials

Nanoparticles For Specific Detection And Killing of Pathogenic Bacteria

pH-Responsive Nanovalves for On-Demand Release of Guest Molecules

Nanoparticles and Imaging Methods for MRI-Guided Stimuli-Responsive Theranostics

Magnetic Actuation of Nanoparticles for Noninvasive Remotely-Controlled Release of Drug

On-Demand Release of Guest Molecules by Using Mesoporous Silica Nanoparticles Equipped with Nanoimpellers

Novel Small Molecule Inhibitors of Endosomal Trafficking for the Treatment of Viral and Bacterial Infection

Mesoporous Silica Nanoparticle Based siRNA/Drug Delivery System
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